Is Therapeutic Drug Monitoring Relevant for Antidepressant Drug Therapy? Implications From a Systematic Review and Meta-Analysis With Focus on Moderating Factors

Introduction Efficacy and safety of antidepressant drug therapy may be limited by inter-individual differences in concentration. Accounting for this inter-individuality, Therapeutic Drug Monitoring (TDM) enables clinicians to adjust dosage based on individual information concentration attained blood. However, research the basic assumption TDM, association between effect, has yielded ambiguous results. It been argued, that ambiguity caused methodological shortcomings studies investigating relationship effect.